DNA damage response and chromatin remodeling
| PAG Title | DNA damage response and chromatin remodeling |
| PAG ID | WIG001825 |
| Type | P |
| Source Link |  Spike |
| Publication Reference | NA |
| PAG Description | The packaging of eukaryotic chromosomal DNA into nucleosomes impedes the access of the DNA repair machinery to damaged DNA. To deal with this obstacle, transient chromatin structural changes are integral to base- and nucleotide-excision, homologous recombination, and non-homologous end joining DNA repair pathways, allowing better accessibility of the DNA repair proteins to the damaged sites, and/or stabilize their recruitment. The chromatin remodeling mechanisms includes: (1) posttranslational modifications (phosphorylations. acetylations, ubiquitination etc.) of histones and non-histones chromatin associated proteins (2) histone-variants replacement, and nucleosomes repositioning or eviction. ATP-dependent multi subunits chromatin remodeling complexes (INO80, SRCAP/SWR-C, SWI/SNF etc.) implement the latter mechanisms. |
| Species | Homo sapiens |
| nCoCo Score | 1,570 |
| Base PAG ID | WIG001825 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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